Título / Title

INTRAVITREAL INJECTION DELIVERED VOLUME UNDER DIFFERENT ENVIRONMENTAL AND TRAINING CONDITIONS

Introdução / Purpose

This study assesses the delivered volume of syringes for intravitreal injection (IVI) under different environmental and training conditions. Recognizing that prior knowledge of syringe characteristics, fluid withdrawal techniques, and color backgrounds may impact the effective volume delivered during IVI, we aimed to evaluate the specific roles of environmental and training conditions.

Material e Método / Methods

Three syringe models (BD Plastipak 1mL, Eylea PFS, and Zero Residual Silicone Oil-free 0.2 mL) were tested with 2 different needle setups (30-g BD PrecisionGlide needle attached to BD Plastipak and Eylea PFS syringes, and 30-g Zero Residual needle attached to its corresponding syringe), with distilled water and a target volume of 50 µL. Two subset of experiments were carried out: different colored backgrounds (beige, black, blue, green, and white) by a single operator, and another at a standard white background, by 3 different operators, under 3 circumstances (no prior training, after proper training, and after specific guidance for overpressure). Ten samples were included in each subgroup. The liquid was expelled into an Eppendorf tube, which was weighed with a 0.1 mg precision scale before and after liquid injection. One-way ANOVA and linear regression were used for statistical analysis.

Resultados / Results

Significant differences in delivered and residual volumes were found among all syringe types (p < 0.01), with the Zero Residual Silicone Oil-Free Syringe being more precise in volume delivery and a much lower residual volume. Operator proficiency, training status and background color also influenced significantly the volume accuracy, however with a trend demonstrating a smaller influence in the Zero Residual syringe tests.

Discussão e Conclusões / Conclusion

Our study revealed significant variations in IVI volumes, influenced notably by syringe type, operator proficiency, and colored backgrounds. These findings emphasize the need to consider materials and techniques for precision in IVI.

Palavras Chave

Intravitreal Injections, Syringes, Medical Education

Area

CLINICAL RETINA

Institutions

Hospital de Olhos de Sergipe - Aracaju - Sergipe - Brasil, Universidade Federal de São Paulo - São Paulo - São Paulo - Brasil

Authors

MATEUS LINS DOS SANTOS, LUCAS ANDRADE SANTOS, ALEXANDRE LIMA CARDOSO, LYDIANNE LUMACK DO MONTE AGRA, GUSTAVO BARRETO DE MELO