Título / Title

OCULAR GROWTH IN CHILDREN WITH CONGENITAL ZIKA SYNDROME: 8-YEAR FOLLOW-UP

Introdução / Purpose

To evaluate the ocular growth of eyes of children with Congenital Zika Syndrome (CZS) measured by ultrasound (US).

Material e Método / Methods

Ambidirectional study conducted at the Altino Ventura Foundation,Brazil with children with CZS. They underwent 2 or 3 ocular US(UltraScan, Alcon) over a 8-year period by the same ophthalmologist that documented the ocular axial length(AL) using the transeyelid B-scan technique. Data was reviewed by a retinal specialist and compared to healthy eyes according to the Sampaolesi ocular growth rate(1st and 2nd measurement) and to Rauscher et al.(3rd measurement). Spherical equivalent(SE), gestational age(GA), head circumference(HC), and birthweight(BW) were collected to analyze with AL measurements. The research was approved by the IRB of FAV and Unifesp(4.422.723 and 4.507.542).

Resultados / Results

Seventy-four eyes of 37 children were analyzed.Twenty-five(67.6%) children were born full-term and 12(32.4%) preterm. Thirty-three(89.2%) children had microcephaly, from which 24(64.9%) was severe. None of the eyes presented congenital cataract or vitreous abnormalities. Infants’ mean age at 1st evaluation was 3.2months old (mo)[SD = 3.3](range,0.2–12.2),20.1[7.7]mo(range,11.2–34.6) at 2nd exam(n=37), and 92.8mo[1.4](range, 90.7–94.3) at the 3rd evaluation (n = 10). The prevalence of ocular growth between the 5th and 50th percentiles was 48/74eyes(64.9%) at 1st evaluation, 36/74(48.6%) at 2nd evaluation, and 13/18(72.2%) at 3rd evaluation. The mean SE of these eyes were 0.3[2.5]diopters (range,-6.0 to +6.0)at the 1st evaluation, -0.2[3.0]diopters (range,-8.0 to +5.0)at the 2nd evaluation, and -2.8[5.8]diopters(range, -12.5 to +2.5)at 3rd evaluation. There wasnt statistically significant correlation between SE, GA, HC, and BW with the AL in all 3 evaluations.

Discussão e Conclusões / Conclusion

The eye growth of children with CZS is similar to typical children.A myopic pattern was observed in the SE evaluation of them that was not correlated to the AL.Birth measurements do not seem to have any relation to this eye growth

Palavras Chave

Zika virus; Microcephaly; Congenital anomalies; Ocular development; Ocular abnormalities.

Area

CLINICAL RETINA

Institutions

ALTINO VENTURA FOUNDATION - RECIFE - Pernambuco - Brasil

Authors

THAYZE MELO MARTINS, ANTÔNIO CASSIANO DINIZ NETTO, NATHALIA SOUZA TEIXEIRA, BRUNA BORBA RAMOS, ADRIANA LIMA GOIS, TACIANA HIGINO, CRISTINA MUCCIOLI, CAMILA VIEIRA VENTURA