Título / Title

PHARMACOLOGICAL THERAPY FOR RELIEVING PAIN IN PANRETINAL PHOTOCOAGULATION: A NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.

Introdução / Purpose

We aim to carry out a systematic review and network meta-analysis to assess pharmacological interventions for relieving pain in patients undergoing PRP.

Material e Método / Methods

PubMed, EMBASE and Cochrane databases were searched systematically. A Bayesian network meta-analysis was conducted to analyze relative efficacy of pain medications and to rank each one according to the Surface Under the Cumulative Ranking Curve (SUCRA). Statistical analysis was performed using R software v. 4.3.2.

Resultados / Results

We included 15 randomized controlled trials and four crossover trials with a total of 1,787 eyes and 45.83% of the participants were female. The mean age of the participants was 55 years. 2% Peribulbar Lidocaine was the only significant treatment compared to placebo MD -2.4 (95% CrI -4.7 to -0.20). The rank probability and SUCRA also revealed 2% peribulbar lidocaine (0.887) as the best treatment in terms of lowering the pain scores followed by Etoricoxib (0.809) and Potassium Diclofenac (0.727).

Discussão e Conclusões / Conclusion

2% peribulbar lidocaine is effective for reducing procedural pain in laser treatment compared to oral and topical medications. Future studies should evaluate drugs that can reach and act on the posterior segment of the eye.

Palavras Chave

Panretinal photocoagulation, diabetic retinopathy, pain, analgesics and anesthetics.

Area

CLINICAL RETINA

Institutions

INSTITUTO PENIDO BURNIER - CAMPINAS - São Paulo - Brasil

Authors

MATEUS PIMENTA ARRUDA, SARA HIRA, RIAN VILAR LIMA, LARISSA IRIGOYEN TEIXEIRA BARBOSA, JOÃO LUCAS DE MAGALHÃES LEAL MOREIRA, MARIANA TOSATO ZINHER, LUBNA AL-SHARIF, GIULIA STEUERNAGEL DEL VALLE