Dados do Trabalho

Título

COMPLEX CASE OF GLOMERULAR DISEASE: UNVEILING THE MYSTERIES OF HYPERTENSION AND RENAL DYSFUNCTION

Relato do Caso

A 32-year-old man presented to the clinic with complaints of hypertension and foamy urine. His medical history revealed a healthy childhood with no known renal problems. However, over the past few months, he had progressively noticed these symptoms. Despite the lack of significant medical history, the patient reported that his father had been diagnosed with chronic kidney disease, which raised concerns about his own renal health. The patient underwent a series of tests, including urine analysis showing significant proteinuria, and blood tests revealing compromised renal function. Suspecting glomerular diseases such as glomerulonephritis, a renal biopsy was performed. Surprisingly, the biopsy results revealed an atypical histological pattern, making an accurate diagnosis challenging. The findings were not consistent with any known glomerular diseases, prompting further investigation. A thorough review of the patient's medical history revealed recent travel to an endemic region for a rare parasitic infection. This raised suspicion that the patient's renal disease could be related to parasitic glomerulonephritis. Additional tests, including serological and imaging studies, were conducted to confirm this hypothesis. However, the results were inconclusive, leaving the medical team perplexed and uncertain about the exact origin of the patient's glomerular disease. After weeks of investigation, a genetic test revealed a rare mutation in a gene associated with familial glomerulopathy, an inherited glomerular disease. This discovery was a surprising turn of events and explained the patient's condition, which had remained unclear until then. Based on the genetic results, a personalized treatment plan was developed, including the use of immunosuppressive medications to reduce inflammation and slow the progression of renal disease. Additionally, measures to control blood pressure and manage proteinuria were prescribed. This case highlights the complexity and importance of thorough investigation in glomerular diseases. The twists and uncertainties throughout the diagnosis required a multidisciplinary approach and creative thinking to reach a conclusion.

Palavras Chave

Hypertension, foamy urine, glomerular diseases, glomerulonephritis, renal biopsy, atypical histological pattern, parasitic glomerulonephritis, genetic test, familial glomerulopathy, immunosuppressive medications.