Dr. Wiebe is a transplant nephrologist with expertise in immunogenetics and the development of de novo donor-specific antibodies in renal transplantation. Related to this proposal he has published on the clinical and pathologic risk factors for de novo donor-specific antibody development. He also has developed expertise in the quantification and identification of the HLA alloepitopes mismatched between donor and recipient HLA alleles and has published on the role these play as predictors of dnDSA development.